【直播】【国际智能与纳米材料杂志】Molly M. Stevens 院士 学术报告

报告题目：

Designing and translating biomaterials for human health：IJSNM杰出讲座系列

报告时间：

2023年2月22日（周三）20:00

报告嘉宾：

Molly M. Stevens 院士（Imperial College London）

主办单位：

国际智能与纳米材料杂志

直播通道

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Prof. Molly M. Stevens

Imperial College London

英国皇家学会院士、英国皇家工程院院士、

美国国家工程院外籍院士、美国艺术与科学院国际荣誉院士

Prof. Molly M Stevens FREng FRS is Professor of Biomedical Materials and Regenerative Medicine and the Research Director for Biomedical Material Sciences in the Department of Materials, in the Department of Bioengineering and the Institute of Biomedical Engineering at Imperial College London. She graduated with a First-Class Honours BPharm degree from Bath University in 1995 and a PhD from the University of Nottingham in 2001. After postdoctoral research in the Langer Lab at MIT, she joined Imperial College London in 2004 as a lecturer and was promoted to Professor in 2008 as one of the youngest Professors ever in the history of the institution. Molly’s multidisciplinary research balances the investigation of fundamental science with the development of technology to address some of the major healthcare challenges. Her work has been instrumental in elucidating the bio-material interfaces. She has created a broad portfolio of designer biomaterials for applications in disease diagnostics and regenerative medicine. Her substantial body of work influences research groups around the world (>400 publications, h-index 98, >39k citations, 2018 and 2021 Clarivate Analytics Highly Cited Researcher in Cross-Field research). Molly holds numerous leadership positions including Director of the UK Regenerative Medicine Platform "Smart Acellular Materials" Hub, Deputy Director of the EPSRC IRC in Early-Warning Sensing Systems for Infectious Diseases and Scientist Trustee of the National Gallery. She is Fellow of the Royal Society and the Royal Academy of Engineering (UK), Foreign Member of the National Academy of Engineering (USA) and International Honorary Member of the American Academy of Arts and Science.

报告摘要

Bio-responsive hybrid materials are of growing importance with potential applications including therapeutic delivery and tissue engineering. In this talk, I will provide an overview of our recent developments in the design of biointerfaces with interesting features such as the incorporation of biological and topographical cues to enhance tissue regeneration, wound healing and cell differentiation. I will show how we are using remote fields for in vivo remote-triggered hydrogelation of lipid based nanocarriers for controlled drug delivery and advanced manufacturing strategies to engineer complex 3D architectures that mimic anisotropic multiscale tissue structures and to generate spatially arranged bioinstructive biochemical and topographical cues. I will discuss our characterisation of single nanoparticles in a high-throughput label-free manner using our patented SPARTA™ technology and how we are exploiting the sensing capabilities of functionalised nanoparticles to engineer nanoprobes for in vivo disease diagnostics that produce a colorimetric response ideal for naked eye read-out and for CRISPR-based preamplification free detection of ncRNAs (CrisprZyme). Finally, I will talk about how we integrate our portfolio of nanoparticle-based sensing probes for diagnosing and monitoring infectious and non-communicable diseases with integration to smartphone technology for mHealth approaches.

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